Respiratory effects of oral mitragynine and oxycodone in a rodent model. Compare the respiratory effects of oral mitragynine to oral oxycodone in rats for evaluating effects of opioids Consistent with mitragynine’s pharmacology that includes partial µ-opioid receptor agonism with little recruitment of the respiratory depressant activating β-arrestin pathway, mitragynine produced no evidence of respiratory depression at doses many times higher than known to be taken by humans. #Kratom #Mitragynine #Oxycodone #Safety #Respiratorydepression #Rat #Animalmodel #Pharmacokinetics #Pharmacodynamics #Opioidepidemic #research #study https://kratomlords.com/kratom-research/respiratory-effects-mitragynine-oxycodone/